Of Mice and Men: Do men really cause stress?


When you walk in the door, Fluffy (your dog, cat, or pet of choice) jumps up, greets you, voices their approval.  He can sense you; she can smell you; he loves you.  What you may not realize is that when Fluffy senses the men in your house, she might become a little stressed out.

You may have heard about this research article published in Nature Methods recently.  I saw this story on the news: men induce stress in laboratory mice.1  I laughed, and then I needed to learn more.  So let us take a brief departure from the seriousness that cancer evokes and discuss how and why men cause stress in mice.

The Science:
This study comes out of Montreal and the laboratory of Jeffrey Mogil.  As a pain geneticist, he studies the factors that determine sensitivity to pain.  His lab staff started to notice and anecdotally reported how their presence might affect the behavior of the laboratory mice.  Could this be true? Or just a researcher’s too-critical eye?  The only way to know for sure was to design some experiments to answer the question: do animals respond differently in response to pain when exposed to male and female researchers?

Cancer Commonalities: The Hallmarks of Cancer Part 3


Welcome to the final discussion on the defining characteristics of cancer.  As we’ve discussed in parts 1 and 2 (Part1Part2) cancer cells share several fundamental traits which are outlined in the figure below. 


Figure 1: Hallmarks of Cancer

In this final discussion, we take a step back:
What allows cancer cells to acquire these traits?  What allows cancer cells to tip the balance on all these processes towards tumorigenesis?  The answer begins with the following two enabling hallmarks.